RO 46-8443

Research use only, not for human use.

RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition.

RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition. The observed parallel rightward shift of concentration-response curves with different antagonist concentrations is consistent with a competitive binding mode. Since R0 46-8443 selectively inhibits ETB receptor mediated responses, it is a valuable tool for clarifying the role of ETB receptors in pathology.

RO 46-8443; RO46-8443; RO-46-8443; RO 468443

Angiogenesis

EGFR

ET-B

——

——

175556-12-4

609.69

C31H35N3O8S

98%

——

c1(ccc(cc1)C(C)(C)C)S(=O)(=O)Nc1nc(nc(c1Oc1c(cccc1)OC)OC[C@@H](CO)O)c1ccc(cc1)OC

4-(tert-butyl)-N-(6-(2,3-dihydroxypropoxy)-5-(2-methoxyphenoxy)-2-(4-methoxyphenyl)pyrimidin-4-yl)benzenesulfonamide

(-20℃)

With Ice Pack

≥ 2 years